girk|Structural insights into GIRK2 channel modulation by cholesterol。,tits beach

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many differegirknt G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.

G Protein-Coupled Inwardly-Rectifying Potassium Channels (GIRK channels) are channels found in the braigirkn that play a crucial role in the inhibitory effects of neurotransmitters.

G-protein-gated inwardly rectifying potassium (GIRK) channels are important for determining neuronal excitability. In addition to G proteins, GIRK channels are potentiated by membrane cholesterol, which is elevated in the brains of people with neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease.

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